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Targeted Molecular Therapy of the PI3K Pathway: Therapeutic Significance of PI3K Subunit Targeting in Colorectal Carcinoma

机译：PI3K通路的靶向分子疗法：PI3K亚基靶向在大肠癌中的治疗意义

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The pattern of distribution of phosphatidylinositol 3-kinase (PI3K) pathway components in human colorectal cancers was analyzed, and the effects of targeted inhibition on in vitro growth and in vivo metastasis using siRNA to p85α or p110α were assessed.

机译：分析了人类大肠癌中磷脂酰肌醇3激酶（PI3K）途径组分的分布模式，并评估了针对siRNA抑制p85α或p110α的靶向抑制作用对体外生长和体内转移的影响。

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Rychahou, Piotr G.; Jackson, Lindsey N.; Silva, Scott R.; Rajaraman, Srinivasan; Evers, B Mark;
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年度 2006
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正文语种 en
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1. Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets [J] . Chen Shuhui, Cavazza Elisa, Barlier Catherine, Oncology letters . 2016,第5aPta2期

机译：除了P53和PTEN：鉴定高级别浆液性卵巢癌中RAS / MAPK和PI3K / AKT信号通路的分子改变，以确定潜在的新型治疗靶点
2. Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets [J] . Chen Shuhui, Cavazza Elisa, Barlier Catherine, Oncology letters . 2016,第5aPta1期

机译：除了P53和PTEN之外：鉴定高级浆液卵巢癌中RAS / MAPK和PI3K / AKT信号传导途径的分子改变，以确定潜在的新疗效目标
3. Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis HCK in erythropoietin/PI3K pathway [J] . Roversi Fernanda Marconi, Pericole Fernando Vieira, Machado-Neto Joao Agostinho, Biochimica et biophysica acta. Molecular basis of disease: BBA . 2017,第2期

机译：造血细胞激酶（HCK）是促红细胞生成素/ PI3K途径的集成，促红细胞生成素/ PI3K途径的促红细胞血液HCH的调节，造血细胞激酶（HCK）是发育障碍和白血病细胞的潜在治疗靶标
4. The Role of the PI3K Pathway in Anti-IgM (Anti-i) - ensitive and -Resistant B-cell Lymphomas Failure to Disengage PI3K Pathway Signaling Confers i-fi Resistance on the CH12 B Cell Lymphoma [C] . Gregory B. Carey, Laura Tonnetti, David W. Scott International Symposium on Programmed Cell Death . 2003

机译：PI3K途径在抗IgM（抗IgM（抗-Ig）的作用 - 最终和 - 抗生素B细胞淋巴瘤未脱离PI3K途径信号传导对CH12 B细胞淋巴瘤的I-FI阻力
5. Molecular profiling of the PTEN/PI3K pathway in sporadic and hereditary breast carcinoma. [D] . Saal, Lao Hayamizu. 2007

机译：PTEN / PI3K途径在散发性和遗传性乳腺癌中的分子谱分析。
6. Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy [O] . Bin Li, Wen Wen Xu, Alfred King Y. Lam, 2017

机译：PI3K / AKT信号通路在食管鳞癌转移中的意义及其作为抗转移靶点的潜力
7. Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy [O] . Li Bin, Xu Wen Wen, Lam Alfred, 2017

机译：PI3K / AKT信号通路在食管鳞癌转移中的意义及其作为抗转移靶点的潜力

Targeted Molecular Therapy of the PI3K Pathway: Therapeutic Significance of PI3K Subunit Targeting in Colorectal Carcinoma

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